Lane made her film debut in the critically acclaimed and award-winning American Honey (2016), a film about magazine crews, written and directed by Andrea Arnold, starring opposite Shia LaBeouf and Riley Keough. Arnold spotted Lane sunbathing on a beach while on spring break. Lane said in an interview that she "felt Arnold's vibe and decided to trust Arnold for an audition."
The film had its world premiere on May 15, 2016 at the Cannes Film Festival, where it won the Prix du Jury. The film was released in a limited release on September 30, 2016, by A24. In 2017, Lane starred in Born in the Maelstrom, a short film directed by Meryam Joobeur, In 2018, Lane starred in Hearts Beat Loud, opposite Nick Offerman and Kiersey Clemons, directed by Brett Haley, and The Miseducation of Cameron Post directed by Desiree Akhavan. The Miseducation of Cameron Post won Top Prize at the 2018 Sundance Film Festival and has been praised for its “sensitive, understated portrayal of adolescent self-doubt and discovery.”
In 2019, Lane will appear in Hellboy, directed by Neil Marshall, and Daniel Isn't Real directed by Adam Eygpt Mortimer.
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